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KMID : 1150320160120020179
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Journal of Korean Society of Geriatric Neurosurgery
2016 Volume.12 No. 2 p.179 ~ p.184
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Clinical Significance of Fascin Expression in Elderly Patients Over 65 Years Old with a Newly Diagnosed Primary Glioblastoma
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Kim Won-Young
Kwon Jeong-Taik
Nam Taek-Kyun
Park Ki-Su
Hwang Jeong-Hyun
Kim Kyoung-Tae
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Abstract
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Objective: The actin-binding protein fascin has been associated with clinically aggressive tumors and poor prognosis. The purpose of this study was to investigate possibility of fascin expression as a prognostic factor in elderly patients over 65 years old with a newly diagnosed primary glioblastoma (GBM).
Methods: Between July 2007 and December 2013, 13 out of 126 patients diagnosed with GBM satisfied the following inclusion criteria: (1) elderly patients over 65 years old, (2) the presence of immunohistochemically-available tissue, (3) a new primary GBM, (4) near-total resection, and (5) standardized adjuvant treatment, known as the Stupp regimen.
Results: The median follow-up period was 18 months (range, 5-95). According to the staining intensity of fascin, progression-free survival (PFS) in the low-intensity fascin group (median PFS, 9.0 months; 95% CI, 6.0-12.0) was longer than PFS in the high-intensity fascin group (median PFS, 7.0 months; 95% CI, 5.6-10.4; p=0.024). Overall survival (OS) in the low-intensity fascin group (median OS, 20.0 months; 95% CI, 17.7-22.4) was longer than OS in the high-intensity fascin group (median OS, 13.0 months; 95% CI, 8.2-17.8; p=0.031). And, the staining intensity of fascin was a statistically significant factor in PFS and OS according to univariate and multivariate analysis (univariate analysis: p=0.043 and p=0.043; multivariate analysis: p=0.041 and p=0.044).
Conclusion: Our clinical study showed that fascin expression intensity may be correlated with clinical outcomes of elderly patients over 65 years old with a newly diagnosed primary GBM, especially with regard to PFS and OS.
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KEYWORD
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Elderly, Glioblastoma, Fascin, Overall, Survival, Progression-free survival
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